In a word, yes!
Compressed air flowing through an air line, whether a rubber hose, a PVC hose, a copper pipe, or black iron pipe, encounters resistance as the air flows along the inner surface of the air line. This slows the flow of compressed air at the edges, yet the air in the middle of the air line is not as affected. This creates turbulence in the compressed air, increasing resistance to flow. The result is flow loss and pressure drop at the air line exit.
If you started with 100′ of 1/2″ rubber hose, and pumped air at 100 PSI into one end of it, you would not get 100 PSI out the other end. It might be close, or quite bit less, depending on the smoothness of the inner air hose surface. Add another 100′ of hose and your pressure at the end of 200′ of run would be less, even though you are still pouring a constant flow of air at 100 PSI into the end. Make the hose longer still, and the yield at the end of an even longer air line would be less.
Then, if you add elbows, angles and tees to the air path, each time you do, you increase resistance to flow, and this costs you in flow and pressure at the point of use.
What can you do about it?
Increase the diameter of the air hose to reduce flow and pressure loss due to turbulence. Keep the number of air fittings to an absolute minimum. Increase the air pressure entering the hose. Starting with a higher air pressure means, even though you will lose flow and pressure due to turbulence in the air line still, the higher the compressed air pressure at the hose beginning will mean more higher pressure and flow at the end.
